Functional models for vanadium haloperoxidase reactivity
Wolf-d woggon, binding of ortho-vanadate anion: the first supramolecular model of of vanadium haloperoxidase (vhpo), oral and poster presentation, international symposium on organic synthesis and catalysis, 23 rd regio symposium,. Mechanistic analysis of nucleophilic substrates oxidation by functional models of vanadium-dependent haloperoxidases: a density functional theory study. Inorganic vanadium (v) peroxo-complexes, some of which have been suggested to be functional models for the vanadium peroxidases , mediate oxygen-transfer reactions to a variety of organic compounds including sulfides . The first documented vanadium enzyme was isolated from red and brown algae and lichens and shown to catalyze a haloperoxidase reaction by producing volatileatmosphere vanadium is also an important regulator of the natural ozone balance in the atmosphere.
The vanadium‐dependent haloperoxidase from the seaweed corallina officinalis has been purified to homogeneity and crystallised the protein is reported to be a hexamer of 12 × 64,000 da, contains no haem, and is dependent on vanadium for activity. Published on web 12/30/2004 reactivity of peroxo forms of the vanadium haloperoxidase cofactor. Oxygen 325 do58 the synthe23is and reactivity of peroxovanadium complexes as models for vanadium haloperoxidase ra d -1 col~a and vincent l pecoraro,.
Vanadium bromoperoxidase and functional mimics vanadium, haloperoxidase, bromoperoxidase, chloroperoxidase, biomimic reactivity of the vanadium haloperoxidases. Role of vanadium in biology functional models for vanadium haloperoxidase: reactivity and results 1 - 25 vanadium-aminocarboxylate complexes: models for the . Published on web 12/30/2004 reactivity of peroxo forms of the vanadium haloperoxidase cofactor of functional models of vhpo9-20 the rate of halide oxidation the . Vanadium haloperoxidases as supramolecular synthetic and computational models the reactivity of related functional mimics containing vanadium and molybdenum. From supramolecular vanadate receptors to enzyme models of vanadium haloperoxidase zhang, xiao-an from supramolecular vanadate receptors to enzyme models of vanadium haloperoxidase 2005, doctoral thesis, university of basel, faculty of science.
Read structural and functional comparisons between vanadium haloperoxidase and acid phosphatase enzymes, journal of molecular recognition on deepdyve, the largest online rental service for scholarly research with thousands of academic publications available at your fingertips. In addition, by studying the bromination reaction activity, it shows that the peroxovanadium complexes can be considered as a potential functional model of bromoperoxidase key words： vanadium haloperoxidase,peroxovanadium complex,crystal structure,catalytic activity. Functional models for vanadium haloperoxidase: reactivity and mechanism of halide oxidation gj colpas, bj hamstra, jw kampf, vl pecoraro journal of the american chemical society 118 (14), 3469-3478 , 1996. Modeling the biological chemistry of vanadium: structural and reactivity studies elucidating structure and function of vanadium in haloperoxidase and nitrogenase .
Iris – institutional research information system model for vanadium-dependent haloperoxidase oxidation by functional models of vanadium-dependent . Functional models for vanadium haloperoxidase: reactivity and mechanism of halide oxidation gerard j colpas, brent j hamstra, jeff w kampf, and vincent l pecoraro. On the selectivity of vanadium haloperoxidase and the nature of the halogenating intermediate many halogenated marine natural products contain chiral carbon-halogen centers or are selectively halogenated or oxidized at sites not expected for reactions by aqueous halogen species (figures 1,2). Functional models for vanadium haloperoxidase: reactivity and mechanism of halide oxidation research paper functional models for vanadium as functional models . Vanadium complexes with tripodal amine ligands already known to be competent models for the halide oxidation by the vanadium haloperoxidases are now shown to model the vhpos' sulfide oxidation activity as well.
Functional models for vanadium haloperoxidase reactivity
Have stimulated the search for structural and functional models based on vanadium complexes moreover, oxovanadium complexes have been attracted tremendous attention for their versatile catalytic properties in organic synthesis. Use epr, eseem (with the frasch and lobrutto groups at arizona state), and endor (with the britt group at uc-davis) to explore spectroscopic models for the reduced form of vanadium haloperoxidase (vhpo) and to acquire a library of data for known compounds so vanadium(iv) can be more widely used as a spectroscopic probe in other biological systems. Protonation of the peroxido structural, electronic, and reactivity properties of an estab- moiety leads to a significant drop in the activation barrier for lished functional model for vanadium-dependent haloper- oxidation. Imidazole-based vanadium complexes as haloperoxidase models for oxidation reactions vanadium-dependant haloperoxidases (vhpos) have been of structural and functional vhpo model complexes4 .
- Vincent l pecoraro, professor at the university of michigan, is a researcher in bioinorganic chemistry and inorganic chemistry he is a specialist in the chemistry and biochemistry of manganese , vanadium , and metallacrown chemistry.
- The vanadium-dependent haloperoxidases exclusively catalyse the oxidation of halides, and act as histidine phosphatases, using histidine for the nucleophilic attack in the first step of the reaction  amino acid residues involved in binding phosphate/vanadate are conserved between the two families, supporting a proposal that vanadium .
- Receptors to enzyme models of vanadium haloperoxidase i the reactivity and selectivity of the reactions catalyzed by v-hpo 9 catalytic activity: functional .
Functional models for vanadium haloperoxidase in the presence of sufficient acid equivalents these complexes catalyze the two-electron oxidation of bromide or iodide by peroxide halogenation of an organic substrate was demonstrated by following the visible conversion of phenol red to bromophenol blue. Density functional theory has been used to investigate the structural, electronic, and reactivity properties of an estab- lished functional model for vanadium-dependent haloper-.